TPN171, CAS 1229018-87-4

Product Description: TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH)[1].

Applications: Neuroscience-Neuromodulation

Formula: C24H35N5O3

References: [1]Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2019 May 23;62(10):4979-4990.

CAS Number: 1229018-87-4

Molecular Weight: 441.57

Compound Purity: 99.41

Research Area: Cardiovascular Disease

Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Phosphodiesterase (PDE)

• SKU: MEXHY-128593-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-128593-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK