trans-AUCB, CAS 885012-33-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[[trans-4-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]cyclohexyl]oxy]-benzoic acid

Purity: ≥90%

Formula Markup: C24H32N2O4

Formula Weight: 412.5

CAS Number: 885012-33-9

Notes: Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects.{14072,12607} trans-AUCB is a very potent inhibitor of sEH (IC50 = 0.5 nM).{19484} It displays high oral bioavailability for doses ranging from 0.01 to 1 mg/kg.{20116,17571} Dual inhibition of COX-2 and sEH, by celecoxib (Item No. 10008672) and trans-AUCB, suppresses tumor angiogenesis, inhibiting tumor growth and metastasis in a Lewis lung carcinoma model in mice.{26684}

• SKU: CAY16568-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16568-1
• Package Unit: 1 mg
• Quantity Unit: STK