Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-[(2R,3R)-2,3-dihydro-6-hydroxy-2-(4-hydroxyphenyl)-4-[(1E)-2-(4-hydroxyphenyl)ethenyl]-3-benzofuranyl]-1,3-benzenediol
Purity: ≥90%
Formula Markup: C28H22O6
Formula Weight: 454.47068
CAS Number: 62218-08-0
Notes: trans-ε-Viniferin is a stilbene polyphenol and dimer of trans-resveratrol (Item No. 70675) that has been found in various red wines and has diverse biological activities.{47517,47518,47519,47520,47521} It induces disaggregation of aggregated amyloid-β (1-42) (Aβ42; Item No. 20574) fibrils in a cell-free assay and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures.{47518} trans-ε-Viniferin reduces cytotoxicity induced by truncated huntingtin (Htt) in PC12 cells (EC50 = 30 nM).{47519} It also reduces production of reactive oxygen species (ROS), mitochondrial dysfunction, and PGC-1α depletion and increases protein levels and deacetylase activity of sirtuin 3 (SIRT3) in cells expressing mutant Htt. trans-ε-Viniferin inhibits calcium-activated chloride channel currents in HT-29 cells (IC50 = ~1 μM).{47520} In vivo, trans-ε-viniferin (2 μg per animal) reduces rotavirus-induced secretory diarrhea in mice without affecting the rotaviral infection. Dietary administration of trans-ε-viniferin reduces hepatic triglyceride accumulation and body weight increases in a mouse model of diet-induced obesity.{47521}
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