Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-acetamide
Purity: ≥95%
Formula Markup: C22H24Cl2N2O4
Formula Weight: 451.3
CAS Number: 1597403-47-8
Notes: Phosphorylation of eIF2α by several kinases in response to cellular stress, including accumulation of unfolded proteins in the ER, results in a decrease in overall protein synthesis but upregulation of a small number of key regulatory proteins. trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay).{27980} Although the mechanism of action is not established, it does not directly inhibit phosphorylation of eIF2α by upstream kinases. trans-ISRIB is able to pass through the blood-brain barrier and significantly enhances learning and memory in mice and rats.{27980}
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