trans-Urocanic Acid, CAS 3465-72-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-(1H-imidazol-5-yl)-2E-propenoic acid

Purity: ≥98%

Formula Markup: C6H6N2O2

Formula Weight: 138.1

CAS Number: 3465-72-3

Notes: trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine.{26632} It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis.{26632} Upon UVB exposure, trans-urocanic acid is converted to the cis isomer, which is known to activate regulatory T cells.{26631}

• SKU: CAY16228-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16228-5
• Package Unit: 5 g
• Quantity Unit: STK