Product Description: Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2].
Applications: COVID-19-immunoregulation
Formula: C19H14ClN3O
References: [1]Du MX, et al. Identification of novel small-molecule inhibitors for human transketolase by high-throughput screening with fluorescent intensity (FLINT) assay. J Biomol Screen. 2004 Aug;9(5):427-33./[2]Mao J, et al. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5320-3.
CAS Number: 419547-73-2
Molecular Weight: 335.79
Compound Purity: 99.59
Research Area: Cancer; Infection
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Bacterial
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