Trilaciclib, CAS 1374743-00-6

Product Description: Trilaciclib (G1T28) is an orally active CDK4/6 inhibitor with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively. . Trilaciclib can effectively inhibit tumor cell proliferation and reduce the hematological toxicity caused by chemotherapy. Trilaciclib attenuates apoptosis and myelosuppression induced by 5FU (HY-90006) chemotherapy[1].

Applications: Cancer-Kinase/protease

Formula: C24H30N8O

References: [1]Bisi JE, et al. Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression. Mol Cancer Ther. 2016 May;15(5):783-93.

CAS Number: 1374743-00-6

Molecular Weight: 446.55

Compound Purity: 99.32

Research Area: Cancer

Solubility: DMSO : 6.73 mg/mL (ultrasonic;warming;adjust pH to 5 with 1 M HCl;heat to 60°C)

Target: CDK

• SKU: MEXHY-101467-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-101467-25
• Package Unit: 25 mg
• Quantity Unit: STK