Application Note: IHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Positive Control: Human cerebral cortex tissue
Form: Liquid
Buffer (with preservative): Batch dependent, 0.09% Sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Uniprot ID: P04629
Antigen Species: Human
Immunogen: Peptide-KLH conjugate with human Trk A (777-796aa)
Purification: Purified IgG
Conjugation: Unconjugated
Full Name: neurotrophic tyrosine kinase, receptor, type 1
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