Product Description: Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.
Applications: Neuroscience-Neuromodulation
Formula: C13H21N3O6
References: [1]Wei HH, et al. NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J Neuroinflammation. 2009 Aug 5;6:19./[2]Lu XC, et al. NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats. J Cereb Blood Flow Metab. 2009 Dec;29(12):1924-32./[3]Cartagena CM, Phillips KL, Williams GL, et al. Mechanism of action for NNZ-2566 anti-inflammatory effects following PBBI involves upregulation of immunomodulator ATF3. Neuromolecular Med. 2013;15(3):504-514.
CAS Number: 853400-76-7
Molecular Weight: 315.32
Compound Purity: 99.30
Research Area: Neurological Disease
Solubility: H2O : ≥ 50 mg/mL/H2O : 110 mg/mL (ultrasonic)
Target: iGluR
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