TRV-120027 TFA

Description: TRV-120027 TFA is an angiotensin II–mediated vasoconstriction inhibitor and increases cardiomyocyte contractility. TRV-120027 TFA is a β-arrestin-1-biased AT1R agonist engaging ß-arrestins while blocking G-protein signaling[1]. TRV-120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling and promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane.

Formula: C45H68F3N13O12

Molecular Weight: 1040,1

References: Liu CH, et al. Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.Nat Commun. 2017 Feb 9;8:14335.

• SKU: TGMTP2158-200mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: TP2158-200mg
• Package Unit: 200 mg
• Quantity Unit: STK