Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]-benzamide
Purity: ≥98%
Formula Markup: C33H35NO6S
Formula Weight: 573.7
CAS Number: 877877-35-5
Notes: TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively).{33641,33642} It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells.{33642} TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously.{33642} It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.{25683}
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