Tz-Thalidomide, CAS 2087490-42-2

Product Description: Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups[1].

Applications: Cancer-programmed cell death

Formula: C29H29N7O6

References: [1]Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2(12):927-934.

CAS Number: 2087490-42-2

Molecular Weight: 571.58

Compound Purity: 98.01

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain;Molecular Glues;PROTACs

• SKU: MEXHY-101460-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-101460-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK