UAA crosslinker 1 (hydrochloride), CAS 1994331-17-7

Product Description: UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases[1]. UAA crosslinker 1 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C9H18ClN5O4

References: [1]Kofoed C, et al. Semisynthesis of an Active Enzyme by Quantitative Click Ligation. Bioconjug Chem. 2019 Apr 17;30(4):1169-1174.

CAS Number: 1994331-17-7

Molecular Weight: 295.72

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 100 mg/mL (ultrasonic)

Target: Biochemical Assay Reagents

• SKU: MEXHY-111434A-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-111434A-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK