UK-122 TFA salt, CAS 1186653-73-5

Description: UK-122 is a potent and selective uPA inhibitor (Ki = 20 nM). The IC(50) of UK122 in a cell-free indirect uPA assay is 0.2 micromol/L. UK122 showed little cytotoxicity against CFPAC-1 cells (IC(50) > 100 micromol/L) but significantly inhibited the migration and invasion of this pancreatic cancer cell line.

CAS Number: 1186653-73-5

Formula: C19H14F3N3O4

Molecular Weight: 405,33

References: Banyard J, Chung I, Migliozzi M, Phan DT, Wilson AM, Zetter BR, Bielenberg DR. Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer. BMC Cancer. 2014 May 30;14:387. doi: 10.1186/1471-2407-14-387. PubMed PMID: 24885350; PubMed Central PMCID: PMC4046438.

• SKU: TGMT29051-10mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T29051-10mg
• Package Unit: 10 mg
• Quantity Unit: STK