Product Description: UNC2025 hydrochloride is a potent, ATP-competitive, and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 hydrochloride is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki?= 13.3 nM). UNC2025 hydrochloride exhibits an excellent PK properties, and can be used for the investigation of acute leukemia[1].
Applications: Cancer-Kinase/protease
Formula: C28H41ClN6O
References: [1]Zhang W, et al. UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor. J Med Chem. 2014 Aug 28;57(16):7031-41./[2]DeRyckere D, et al. UNC2025, a MERTK Small-Molecule Inhibitor, Is Therapeutically Effective Alone and in Combination with CL14377 in Leukemia Models.Clin Cancer Res. 2017 Mar 15;23(6):1481-1492.
CAS Number: 2070015-17-5
Molecular Weight: 513.12
Compound Purity: 99.87
Research Area: Cancer
Solubility: DMSO : 10 mg/mL (ultrasonic)/H2O : 55 mg/mL (ultrasonic)
Target: FLT3
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