Product Description: UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].
Formula: C24H34FN7O2
References: [1]McIver AL, et al. Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem. 2017 Feb 3;12(3):207-213.
CAS Number: 1612782-86-1
Molecular Weight: 471.57
Compound Purity: 99.71
Research Area: Others
Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target: TAM Receptor