Unesbulin, CAS 1610964-64-1

Product Description: Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity[1][2].

Applications: Cancer-Kinase/protease

Formula: C19H13F5N6

References: [1]Nishida Y, et al. The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood Cancer J. 2017 Feb 17;7(2):e527./[2]BMI1 inhibitor PTC596

CAS Number: 1610964-64-1

Molecular Weight: 420.34

Compound Purity: 99.45

Research Area: Cancer

Solubility: DMSO : 16.67 mg/mL (ultrasonic)

Target: Apoptosis;BMI1

• SKU: MEXHY-112041-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-112041-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK