Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-cyclohexyl-carbamic acid, 3'-(aminocarbonyl)-6-hydroxy[1,1'-biphenyl]-3-yl ester
Purity: ≥95%
Formula Markup: C20H22N2O4
Formula Weight: 354.4
CAS Number: 1357160-72-5
Notes: URB937 is a potent fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 26.8 nM, in vitro) that does not penetrate the blood-brain barrier, thus preventing arachidonoyl ethanolamide (AEA; Item No. 90050) deactivation only in peripheral tissues.{18772} Its ED50 value for FAAH inhibition in brain is 200-fold higher than the ED50 value for FAAH inhibition in liver when administered systemically in mice (40 mg/kg versus 0.2 mg/kg, respectively). Subcutaneous administration of URB937 reduces acetic acid-induced writhing in mice with an ED50 value of 0.1 mg/kg. A single 1 mg/kg injection of URB937 sufficiently attenuates behavioral responses elicited in mouse models of neuropathic and inflammatory pain. As a peripherally-specific FAAH inhibitor, URB937 may offer an alternative approach to pain therapy devoid of unwanted central effects.
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