Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine
Purity: ≥95%
Formula Markup: C27H27N5
Formula Weight: 421.5
CAS Number: 1229582-33-5
Notes: URMC-099 is an orally bioavailable, brain-penetrant inhibitor of mixed-lineage kinases (MLKs) with IC50 values of 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively.{19147} It also inhibits LRRK2 activity with an IC50 value of 11 nM.{19147} In vitro, URMC-099 has been shown to reduce inflammatory cytokine production by HIV-1 Tat-exposed microglia and to prevent destruction and phagocytosis of cultured neuronal axons by these cells.{31033} In rodent models of HIV-associated neurocognitive disorders, URMC-099 demonstrates anti-inflammatory and neuroprotective effects.{31033}
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