Target: UVRAG
Conjugate: RPE
Product Type: Polyclonal
Immunogen: Synthetic peptide from the mid-protein of human UVRAG
Swiss-Prot: Q9P2Y5
Purification: Peptide Affinity Purified
Storage Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Concentration: 1 mg/ml
Specificity: Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.
Cellular Localization: Endosome / Lysosome / Endoplasmic reticulum / Nucleus / Chromosome / Centromere
Scientific Background: UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (1). Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (2). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (3-4). It is highly expressed in the brain, lung, kidney and liver.
References: 1. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87.2. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87.3. Ionov, Y. et al. (2004) Oncogene. 23: 639-45.4. Kim, M.S. et al. (2008) Hum Pathol. 39: 1059-63.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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