Product Description: Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory agent and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects[1][2].
Applications: COVID-19-immunoregulation
Formula: C22H28O4
References: [1]Heier CR, et al. VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects. EMBO Mol Med. 2013 Oct;5(10):1569-85./[2]Dillingham BC, et al. VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimmune encephalomyelitis. Cell Mol Neurobiol. 2015 Apr;35(3):377-387./[3]Heier CR, et al. Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy. Life Sci Alliance. 2019 Feb 11;2(1). pii: e201800186.
CAS Number: 13209-41-1
Molecular Weight: 356.46
Compound Purity: 99.10
Research Area: Inflammation/Immunology
Solubility: DMSO : 62.5 mg/mL (ultrasonic)
Target: Glucocorticoid Receptor;Mineralocorticoid Receptor;NF-κB
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