Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 7-(2-benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
Purity: ≥98%
Formula Markup: C18H12N6OS
Formula Weight: 360.4
CAS Number: 722456-31-7
Notes: VAS2870 is a selective inhibitor of the NADPH oxidases.{34568,34569,34570,34593} Pre-incubation of rat vascular smooth muscle cells with VAS2870 abolishes platelet-derived growth factor-dependent chemotaxis without affecting cell cycle progression (IC50 = 10 µM).{34568} At low (2.8 mM), but not high (16.7 mM), concentrations of glucose, treatment with VAS2870 (20 µM) increases glucose-stimulated insulin secretion of rat pancreatic islets by 70%.{34575} It significantly reduces production of reactive oxygen species in mouse brain, rat vascular smooth muscle culture, and human umbilical vein endothelial cells.{34568,34571,34572} Treatment with VAS2870 pre- or post-ischemia is neuroprotective in mouse brain.{34571} VAS2870 inhibits vasculogenesis of mouse embryonic stem cell cultures and inhibits cell proliferation of rat hepatoma cells.{34573,34574}
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