Target Synonym: VASH1;KIAA1036
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunogen: Recombinant fusion protein of human VASH1
Dilution: WB 1:500-1:2000
Calculated MW: 21kDa/40kDa
Observed MW: 41kDa
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