Vatalanib (hydrochloride), CAS 212141-51-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, dihydrochloride

Purity: ≥98%

Formula Markup: C20H15ClN4 / 2HCl

Formula Weight: 419.7

CAS Number: 212141-51-0

Notes: Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively.{24346,24345} It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases.{24346,24344,24345} Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.{18281,24343}

• SKU: CAY14868-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 14868-25
• Package Unit: 25 mg
• Quantity Unit: STK