Target: VDAC1
Conjugate: ATTO 488
Product Type: Monoclonal
Clone Number: N152B/23 (Formerly sold as S152B-23)
Immunogen: Fusion protein amino acids 1-283 (full-length) of human VDAC1. Mouse: 98% identity (279/283 amino acids identical). Rat: 98% identity (279/283 amino acids identical) >60% identity with VDAC2 and VDAC3.
Swiss-Prot: P21796
Purification: Protein G Purified
Storage Buffer: 640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS
Concentration: 1 mg/ml
Specificity: Detects ~30kDa. Does not cross-react with VDAC2 or VDAC3 (based on KO validation results).
Cellular Localization: Mitochondrion / Mitochondrion Outer Membrane / Cell Membrane
Scientific Background: Voltage-dependent anion-selective channel protein 1 (also known as VDAC, VDAC1 or outer mitochondrial membrane protein porin 1) is the the outer mitochondrial membrane receptor for hexokinase and BCL2L1. VDAC forms a channel through the mitochondrial membrane and is involved in small molecule diffusion, cell volume regulation and apoptosis. VDAC may participate in the formation of the permeability transition pore complex (PTPC), which is responsible for the release of mitochondrial products that triggers apoptosis.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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