Description: This MAb is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: DC101
Immunogen: Recombinant full-length Mouse VEGFR2 protein
Antibody Reactivity: CD309/Flk-1/KDR3/VEGF-R2
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- Cancer Metastasis Rev (1998) 17(2):155-61. (functional studies)
- J Exp Med (2001) 193(9): 1005-1014. (Flow)
- FASEB J (2005) 19(14): 2005-2007. (IHC, frozen)
Entrez Gene ID: 16542
Expected AB Applications: IHC (frozen) (published for clone)/Flow, surface (published for clone)/Functional studies (published for clone)
Z-Antibody Applications: Flow, surface (published)/Functional studies (published)/IHC, frozen (published)
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