Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methyl-d3-amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C27H35D3N2O4 / HCl
Formula Weight: 494.1
CAS Number: 2714485-49-9
Notes: (±)-Verapamil-d3 (hydrochloride) (Item No. 18452) is intended for use as an internal standard for the quantification of verapamil (Item No. 14288) by GC- or LC-MS. Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions.{22485} Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC50 = 0.38 μM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches.{22481,22479,22478} Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines.{20755}
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