Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-a-(dimethylamino)-3-thiopheneacetamide
Purity: ≥98%
Formula Markup: C17H17N3O2S
Formula Weight: 327.4019
CAS Number: 1414854-42-4
Notes: A ROCK1 and ROCK2 inhibitor (Ki = 2 nM for both); selective for ROCK1 and ROCK2 over PKA, PKCθ, MRCKα, and CaMKIV (Kis = 69, 9,332, 28, and 5,855 nM, respectively); decreases focal adhesion points on, and actin fiber length in, primary PTM cells at 1 µM; inhibits TGF-β-induced increases in α-SMA levels in primary human conjunctival fibroblasts at 250 or 500 nM; inhibits TGF-β-induced migration in a wound healing assay using primary human conjunctival fibroblasts; reduces IOP in rabbits and Formosan rock monkeys when ocularly administered at 0.5%; decreases IOP and subconjunctival collagen levels in a rabbit model of trabeculectomy when ocularly administered at 0.5%
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