Product Description: Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C17H17N3O2S
References: [1]Lin CW, Sherman B, Moore LA, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34(1-2):40‐51./[2]Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013;97(5):567‐572.
CAS Number: 1414854-42-4
Molecular Weight: 327.40
Compound Purity: 99.18
Research Area: Neurological Disease
Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
Target: ROCK
English
Deutsch
