VH032-cyclopropane-F, CAS 2306193-99-5

Product Description: VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1].

Applications: Cancer-programmed cell death

Formula: C26H33FN4O5S

References: [1]Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680./[2]Liu J, et al. FAK-targeting PROTAC demonstrates enhanced antitumor activity against KRAS mutant non-small cell lung cancer. Exp Cell Res. 2021 Nov 15;408(2):112868.

CAS Number: 2306193-99-5

Molecular Weight: 532.63

Compound Purity: 99.92

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Ligands for E3 Ligase

• SKU: MEXHY-125905-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-125905-10
• Package Unit: 10 mg
• Quantity Unit: STK