VH 298, CAS 2097381-85-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity: ≥98%

Formula Markup: C27H33N5O4S

Formula Weight: 523.7

CAS Number: 2097381-85-4

Notes: VH 298 is a cell-permeant inhibitor of von Hippel-Lindau disease tumor suppressor (VHL; Kd = 90 nM by isothermal titration calorimetry).{32855} VHL is a component of the complex that polyubiquitinates hydroxylated hypoxia-inducible factor-α (HIF-α) isoforms leading to proteasomal degradation. Through its effects on VHL, VH 298 promotes the accumulation of HIF-α in a concentration- and time-dependent manner, resulting in the upregulation of HIF-target genes.{32855}

• SKU: CAY21133-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 21133-25
• Package Unit: 25 mg
• Quantity Unit: STK