Vildagliptin, CAS 274901-16-5

Anti-diabetic agent

Product Type: Inhibitor

CAS No.: 274901-16-5

MolecularFormula: C17H25N3O2

Molecular Weight: 303,4

Source: Synthetic

Purity: >98% (HPLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml)

Appearance: White powder

PubChem CID: 11077541

Scientific Background: Vildagliptin is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1) (1). Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia) (2). It is a clinically useful antidiabetic agent. Ameliorates cognitive deficits in streptozotocin-induced Alzheimers disease model (3). Displays protective effects on βcells by inhibition of ER stress in a mouse model (4). Clinically useful antidiabetic agent.

References: 1.B Balas et al. J. Clin. Endocrinol. Metab. 2007 92:12492.B Ahren et al. J. Clin. Endocrinol. Metab. 2004 89:20783.J Kosaraju et al. J. Pharm. Pharmacol. 2013 65:17734.S Shimizu et al. J. Mol. Endocrinol. 2012 49:125

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-567-20MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-567-20MG
• Package Unit: 20 mg
• Quantity Unit: STK