Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (OC-6-45)-aqua(3-hydroxy-2-pyridinecarboxylato-?N1,?O2)[3-(hydroxy-?O)-2-pyridinecarboxylato(2-)-?O2]oxo-vanadate(1-), hydrogen, trihydrate
Purity: ≥95%
Formula Markup: C12H9N2O8V / H [3H2O]
Formula Weight: 415.2
CAS Number: 476310-60-8
Notes: VO-OHpic is a specific inhibitor of phosphatase and tensin homolog (PTEN; IC50 = 35 nM in vitro).{14756,33941} Through this action, it increases cellular phosphatidylinositol 3,4,5-trisphosphate (PIP3) levels, phosphorylation of Akt, and glucose uptake in adipocytes.{14756} In mice, VO-OHpic (10 µg/kg, i.p.) decreases left ventricular systolic pressure and heart rate and protects against ischemia/reperfusion-induced myocardial infarction.{33944} VO-OHpic also blocks the development of suppressor activity in regulatory T cells activated with indoleamine 2,3-dioxygenase.{33942}
English
Deutsch
