Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 6-(6-chloro-2-pyridinyl)-N2,N4-bis[(1R )-2,2,2-trifluoro-1-methylethyl]-1,3,5-triazine-2,4-diamine
Purity: ≥98%
Formula Markup: C14H13ClF6N6
Formula Weight: 414.736579
CAS Number: 1644545-52-7
Notes: Vorsidenib is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively).{45449} It also inhibits wild-type-IDH1R132H and wild-type-IDH2R140Q heterodimers (IC50s = 4 and 251 nM, respectively).{45451} Vorsidenib decreases the production of D-2-hydroxyglutarate (2-HG; Item Nos. 25895 / 11605) in TF-1 leukemia cells expressing IDH1R132H or IDH2R140Q (IC50s = 3.2 and 14 nM, respectively). It reduces tumor growth in a TS603-IDH1R132H mouse xenograft model when administered at a dose of 50 mg/kg.{45450}
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