Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-(3-chlorophenyl)-2-pyridinecarboxamide
Purity: ≥98%
Formula Markup: C12H9ClN2O
Formula Weight: 232.7
CAS Number: 61350-00-3
Notes: VU0364770 is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4; EC50 = 1.1 µM in a calcium mobilization assay).{45499} It is also a positive allosteric modulator of mGluR6 (EC50 = 6.8 µM) and an antagonist of mGluR5 (IC50 = 17.9 µM). VU0364770 binds to monoamine oxidase A (MAO-A) and MAO-B (Kis = 8.5 and 7.2 µM, respectively), as well as the human norepinephrine transporter in a panel of 68 receptors, ion channels, and transporters at 10 µM. It decreases haloperidol-induced catalepsy and reduces increases in the number of premature reactions in response to a light cue, indicating improved attentional control, in a 6-hydroxydopamine (6-OHDA; Item No. 25330) rat model of Parkinson’s disease when administered at a dose of 56.6 mg/kg.
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