Product Description: VU0467485 (AZ13713945) is a potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator (PAM). VU0467485 (AZ13713945) potentiates activity of ACh at M4 with EC50s of 26.6 nM and 78.8 nM at rat and human M4 receptors, respectively. VU0467485 (AZ13713945) shows selectivity for M4 over human and rat M1/2/3/5. VU0467485 (AZ13713945) displays moderate to high CNS penetration. VU0467485 (AZ13713945) has antipsychotic-like activity[1].
Applications: Neuroscience-Neuromodulation
Formula: C17H17FN4O2S
References: [1]Wood MR, et al. Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia. ACS Med Chem Lett. 2016 Dec 16;8(2):233-238.
CAS Number: 1451994-10-7
Molecular Weight: 360.41
Compound Purity: 99.0
Research Area: Neurological Disease
Solubility: DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
Target: mAChR
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