WHI-P154, CAS 211555-04-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol

Purity: ≥98%

Formula Markup: C16H14BrN3O3

Formula Weight: 376.2

CAS Number: 211555-04-3

Notes: WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50 = 1.8 μM versus IC50s > 10 μM for JAK1 and JAK2).{26468} It has been reported to inhibit additional kinases including EGFR (IC50 = 4 nM) and VEGFR as well as the non-receptor tyrosine kinases, Abl, Lck, and Src.{26468} WHI-P154 is cytotoxic to human glioblastoma cells (IC50 = 813 nM) and has been used to induce the differentiation of neuronal precursor cells.{26470,26471,26469}

• SKU: CAY16178-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16178-5
• Package Unit: 5 mg
• Quantity Unit: STK