WHI-P180, CAS 211555-08-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol

Purity: ≥98%

Formula Markup: C16H15N3O3

Formula Weight: 297.3

CAS Number: 211555-08-7

Notes: WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR), respectively.{40380} It also inhibits EGFR (IC50 = 4 μM) and binds to tau-tubulin kinase 1 (TTBK1; Kds = 0.46 and 0.24 μM for phosphorylated and non-phosphorylated TTBK1, respectively).{40381,40382} WHI-P180 inhibits JAK3 and JAK3-driven graft versus host disease responses in mice receiving allogenic bone marrow and splenocyte grafts.{40381,40383} WHI-P180 (25 mg/kg, i.p) inhibits IgE-induced vascular hyperpermeability in a mouse model of passive anaphylaxis.{40384}

• SKU: CAY23452-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 23452-1
• Package Unit: 1 mg
• Quantity Unit: STK