WHI-P258, CAS 21561-09-1

Product Description: WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C16H15N3O2

References: [1]Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82./[2]Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22.

CAS Number: 21561-09-1

Molecular Weight: 281.31

Compound Purity: 99.61

Research Area: Cancer

Solubility: DMSO : 31.25 mg/mL (ultrasonic)

Target: JNK

• SKU: MEXHY-108419-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-108419-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK