WNK-IN-11, CAS 2123489-30-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-methanone

Purity: ≥98%

Formula Markup: C21H21Cl2N5OS

Formula Weight: 462.39594

CAS Number: 2123489-30-3

Notes: WNK-IN-11 is an allosteric inhibitor of lysine-deficient protein kinase 1 (WNK1; IC50 = 4 nM).{52277} It is 57- and 1000-fold selective for WNK1 over WNK2 and WNK4, respectively, as well as a panel of 400 kinases at 10 µM. It inhibits WNK1-mediated phosphorylation of the transcription factor OSR1 in HEK293 cells (EC50 = 0.352 µM).

• SKU: CAY29676-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29676-50
• Package Unit: 50 mg
• Quantity Unit: STK