WX8, CAS 232935-92-1

Product Description: WX8 (Ro 91-4714) is an ATP-competitive PIKFYVE inhibitor, with Kd values of 0.9 nM and 340 nM for PIKFYVE and PIP4K2C, respectively. WX8 (Ro 91-4714) inhibits lysosomal fission without effecting homotypic lysosomal fusion. WX8 (Ro 91-4714) is used in the research of autophagy-dependent cancer[1].

Applications: Cancer-Kinase/protease

Formula: C22H22N8O

References: [1]Ajit Roy, et al. Selective Termination of Autophagy-Dependent Cancers. Cells. 2024 Jun 25;13(13):1096./[2]Gaurav Sharma, et al. A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis. Autophagy. 2019 Oct;15(10):1694-1718.

CAS Number: 232935-92-1

Molecular Weight: 414.46

Research Area: Cancer

Target: PIKfyve

• SKU: MEXHY-159625-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-159625-50
• Package Unit: 50 mg
• Quantity Unit: STK