Product Description: Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
Applications: Metabolism-protein/nucleotide metabolism
Formula: C16H26ClNO2
References: [1]Otton, et al. Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br. J. Clin. Pharmacol. 41(2), 149-156 (1996).
CAS Number: 93413-90-2
Molecular Weight: 299.84
Compound Purity: 99.65
Research Area: Metabolic Disease
Solubility: DMSO : 116.67 mg/mL (ultrasonic)
Target: Serotonin Transporter
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