Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-2-propenamide
Purity: ≥98%
Formula Markup: C23H13F9N4O3S
Formula Weight: 596.4
CAS Number: 725247-18-7
Notes: XCT790 is an inverse agonist of estrogen-related receptor α (ERRα; IC50 = ~300-500 nM).{31192,31194} It demonstrates 90-100% inhibition of ERRα constitutive activity and has no significant activity at related nuclear receptors at 10 µM.{31194} XCT790 associates with the ligand-binding domain of ERRα and blocks ERRα/PGC-1α-dependent signaling, suppressing the expression of monoamine oxidases A and B.{31194} XCT790 induces proteasomal degradation of ERRα and potentiates the degradation of the estrogen receptor ERα by fulvestrant (Item No. 10011269).{31193}
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