Y-27632 (hydrochloride), CAS 129830-38-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: trans-4-[(1R)-1-aminoethyl]-N-4-pyridinyl-Cyclohexanecarboxamide, dihydrochloride

Purity: ≥98%

Formula Markup: C14H21N3O / 2HCl

Formula Weight: 320.3

CAS Number: 129830-38-2

Notes: The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM.{12847,15085} One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages.{17322}

• SKU: CAY10005583-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10005583-10
• Package Unit: 10 mg
• Quantity Unit: STK