Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[2-(5-chloro-2-pyridinyl)ethyl]-4-[[[(4-methoxyphenyl)sulfonyl]amino]methyl]-benzamide
Purity: ≥95%
Formula Markup: C22H22ClN3O4S
Formula Weight: 459.9
CAS Number: 1943733-16-1
Notes: YU238259 is an inhibitor of homology-dependent DNA repair (HDR) that is lethal to BRCA2-/- but not BRCA2+/+ PEO1/4 cells (LD50s = 8.7 and >100 μM, respectively).{42297} YU238259 selectively inhibits HDR over non-homologous end joining (NHEJ), decreasing the number of U20S cells with ionizing radiation-induced BRCA1 foci but not 53BP1 or pDNA-PK foci. It also increases the number of ionizing radiation-induced double strand breaks (DSBs) in DLD-1 cells. YU238259 (1-20 μM) is cytotoxic to BRCA2-/- DLD-1, ATM-/- GM05849, and PTEN-/- U251 cells but has no effect on wild-type cells. In vivo, YU238259 (3 mg/kg) delays tumor growth and increases survival in a BRCA2-/-, but not a BRCA+/+, DLD-1 mouse xenograft model.
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