ZIP acetate(863987-12-6 free base)

Description: ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Formula: C92H158N30O19

Molecular Weight: 1988,43

References: Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141 PMID:

• SKU: TGMTP1924L1-200mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: TP1924L1-200mg
• Package Unit: 200 mg
• Quantity Unit: STK