Product Description: ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.
Applications: Cancer-Kinase/protease
Formula: C23H26ClNO
References: [1]Brown GR, et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9./[2]Lai TS, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78./[3]Zhang Z, et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197.
CAS Number: 1021868-92-7
Molecular Weight: 367.91
Compound Purity: 98.19
Research Area: Cancer; Neurological Disease
Solubility: DMSO : ≥ 47 mg/mL/H2O : 1 mg/mL (ultrasonic)
Target: JAK
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