Clone Name: 5A4
Product Description: Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells, which express CD30 antigen and the epithelial membrane antigen (EMA). These tumor cells tend to occur in younger patients and may be associated with cutaneous and extranodal involvement. Large cell lymphoma account for approximately 25% of all non-Hodgkin lymphomas in children and young adults.
Application Note: IHC-P: 1:25-1:140. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 176
Positive Control: Anaplastic Lymphoma
Form: Liquid
Buffer (with preservative): Tissue culture supernatant, 0.09% sodium azide.
Concentration: Batch dependent
Background: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
Uniprot ID: Q9UM73
Immunogen: Prokaryotic recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of NPM-ALK transcript (419-520 aa).
Purification: Unpurified
Conjugation: Unconjugated
Full Name: ALK receptor tyrosine kinase
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