Shelf life (days): 1460.0
Formulation: A neat oil
Formal Name: (3S,4E)-4-formyl-3-(2-oxoethyl)-4-hexenoic acid, 2-(3,4-dihydroxyphenyl) ethyl ester
Purity: ≥95%
Formula Markup: C17H20O6
Formula Weight: 320.3371
CAS Number: 149183-75-5
Notes: Oleacein is a secoiridoid polyphenol that has been found in O. europea and has diverse biological activities.{66824,66825,66826,66827} It inhibits 5-lipoxygenase (5-LO; IC50 = 2 µM for the human enzyme).{66824} Oleacein (20 and 50 µM) reduces lipid accumulation and inhibits the transition into foam cells in human monocyte-derived macrophages.{66825} It decreases lipid accumulation and levels of peroxisome proliferator-activated receptor γ (PPARγ) and fatty acid synthase (FASN), as well as increases adiponectin levels, in 3T3-L1 adipocytes.{66826} In vivo, oleacein (20 mg/kg) reduces macrophage and lymphocyte infiltration in abdominal fat tissue and adipocyte size in a mouse model of high-fat diet-induced obesity. Oleacein also delays disease onset and progression in a mouse model of experimental autoimmune encephalomyelitis (EAE).{66827}
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