ZG-2033, CAS 2685739-28-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-(3,5-dimethoxyphenyl)-1,2-benzisothiazol-3-amine

Purity: ≥98%

Formula Markup: C15H14N2O2S

Formula Weight: 286.3

CAS Number: 2685739-28-8

Notes: ZG-2033 is an agonist of hypoxia-inducible factor 2α (HIF-2α).{68874} It induces HIF-2α transcriptional activity in a reporter assay using 786-O cells expressing HIF-2α (EC50 = 0.49 µM). ZG-2033 (10 or 50 µM), in combination with the inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 AKB-6548 (vadadustat; Item No. 15295), increases the number of erythrocytes in a zebrafish model of doxorubicin-induced anemia. It increases the plasma levels of erythropoietin (EPO) in mice when administered at concentrations of 100 or 200 mg/kg in combination with vadadustat.

• SKU: CAY41672-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41672-1
• Package Unit: 1 mg
• Quantity Unit: STK